Check whether you have write permission to the location where the new/edited bin ranges are saved. The file is called binning.xml and in ioGAS version 4.5 is located in the user configuration area (C:\Users\username\AppData\Roaming\ioGAS). In ioGAS version 4.4 and before, the file is located in the data folder in the ioGAS installation folder, eg. C:\Program Files\ioAnalytics\ioGAS\data. If you do not have write permission to the Program Files area then you cannot save any new bin ranges.